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According to the exploration results of the T1D patients or models, the following bacteria were mainly increased in abundance: Bifidobacterium longum (166, 167), Eubacterium rectale (168), Bacteroides uniformis (169), Lachnospira spp., Intestinimonas spp., Micrococcales spp (170)., Actinomyces spp (171)., Bacteroides spp (172)., Prevotella spp (168)., Ruminococcus spp (173)., and Veillonella spp (174)., whereas the bacterium with decreased abundance mainly includes butyrate-producing bacterium, lactic acid-producing bacterium, and mucin-degrading bacterium, such as Lactococcus , Lactobacillus ( 173), Streptococcus (174), Bifidobacterium , Proteobacteria (172), Subdoligranulum , Roseburia , Eubacterium , Anaerostipes (175), FP (176, 177), Clostridium clusters IV (178, 179), and XIVa (180, 181)

considering the brain and the CNS specifically, BBB penetration rates and the P-glycoprotein (P-gp) efflux pump are critical factors limiting their application in the clinic [1]

BPC-157, TB-500, and IGF-1 LR3 have no completed human trials at all

This is a known pharmacological effect documented in the WHOs clinical monograph on phentermine