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Subsequently, MeCbl donates its methyl group to homocysteine, thereby converting it to methionine (Figure 2) while being reduced back to cobalamin

Numerous additional questions remain regarding the catabolism of metabolites and their impact on tissue homeostasis in disease

Fanucchi, S

This highly conserved enzyme is a member of the phosphoinositide 3-kinase (PI3K)-related kinase family [24]

Some mutations can lead to various neurological conditions, including neonatal mitochondrial encephalopathy, sensorineural hearing loss, axonal neuropathy, and, less commonly, motor neuron disease ( Riboflavin also supports the antioxidant defense system by aiding the regeneration of other antioxidants, such as glutathione, from oxidized glutathione (GSSG), since riboflavin, in the form of FAD, is necessary for glutathione reductase to play its role in converting GSSG (43)