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While toll-like receptors (TLRs) signaling ensures protective immune response by recognizing invading pathogens and tissue-derived endogenous molecules, its overactivation perturbs the immune homeostasis by sustained release of pro-inflammatory mediators and subsequently underlies the development of many inflammatory diseases [296]

Network pharmacology provides new insights into the mechanism of traditional Chinese medicine and natural products used to treat pulmonary hypertension

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nitrated Prx2 resembles its disulfide-oxidized form

123 , 124 Furthermore, external factors (eg, solution pH) and possible external irradiation significantly influence the pro- or antioxidant capabilities of NMs