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Neuro-post acute sequelae of COVID was of particular interest to ME/CFS and was identified by 69 differentially expressed metabolites including elevated sphinganine and ST1A1, disordered sphingolipid metabolism, and attenuated inflammatory responses 50

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Notably, semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist originally developed for T2DM and obesity, has shown robust efficacy in achieving resolution of steatohepatitis, underscoring its potential for repurposing in MASLD management [94]

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