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[DOI] [PubMed] [Google Scholar] 194.Pavlides C., Watanabe Y., McEwen B.S

Data represented as mean SD, unpaired t-test

By inhibiting the excessive activation of N-methyl-D-aspartate receptor (NMDAR), binding to calmodulin, and regulating calcium-dependent kinases such as Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and PKC, melatonin prevents excitotoxicity and activation of calcium-dependent caspases

hence, carbidopa or benserazide is always coadministered to ensure adequate central bioavailability [96]

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