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For competition experiments the cells were pre-treated with 1 M Carfilzomib, 1 M MLN4924 or 500 nM TAK243 for 1 h before the addition of SP3N or co-treated with different concentrations of SLF and SP3N

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Disruption of ATP availability causes deprived ion transport, leading to elevated intracellular Ca 2+ levels, activation of the Gardos channel, cellular dehydration, and diminished deformability (29, 30)

The surface modification of the liposome with ligands (antibodies or peptides) ensures targeted delivery to dopaminergic neurons, which could improve their targeting capabilities and efficacy and reduce side effects

Survival percentages were calculated by dividing the number of surviving cells after exposure to 20 mM H 2 O 2 by the initial cell count prior to the stress treatment