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In particular, a systematic review of 5632 patients concluded that augmentation therapy has a slight effect in reducing the decline in lung function, showing a 23% slowdown in the decline of forced expiratory volume in one second (FEV1) (13.4 mL/year, 95% CI 1.5-25.3 mL/year) in treated patients compared to the placebo group (83)
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The authors used differentiated dopaminergic neurons (DN) from patients-iPSC, which are involved in the pathology of LS, and they observed that SURF1 mutant DNs showed a reduced number of neurons, as well as defects in neuronal maturation

Table 1 Key immune cells involved in tendon inflammation
