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Acetaminophen is metabolized in the liver where a toxic byproduct is produced that can be removed by conjugation with glutathione

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Because these drugs can disrupt the bloodaqueous barrier, they should be avoided in patients with uveitic glaucoma

GlyT1 inhibitor M22 treatment increased the seizure threshold in a mouse model of the maximal electroshock seizure threshold (MEST) test without affecting motor function, suggesting its potential as a new anticonvulsive drug but in this same study M22 was ineffective in altering the seizure threshold as assessed by the PTZ infusion test (Zhao et al

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