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It comprises a network of soluble and cell membrane proteins that work in a coordinated manner, which can be activated by antigen-antibody complexes (classical pathway, CP), carbohydrates (lectin pathway, LP), or by a variety of surfaces that are not protected by natural inhibitors (alternative pathway, AP)

Emerging evidence suggests that activated microglia compete with neurons for metabolic substrates during inflammation [19]

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Further, NO reduces oxidative phosphorylation by nitrosylation, inhibiting proteins involved in the mitochondrial electron transport chain

, Kim1 expression increased with higher doses of sulfasalazine (Supplemental Figure 6), suggesting a dose-dependent nephrotoxic effect