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Estrogens may act either by an epigenetic pathway in which DNA is not chemically altered or they may be metabolized to products that damage DNA (Monks and Lau, 1994)

In the context of an autoimmune diseasewhere the immune system is already misfiring and attacking the body's own tissuesintroducing a powerful new modulator is unpredictable
Further, the products of the GGT reaction may themselves lead to an increased free radical production

Figure 2 Using immunoassay, adults with T1D had plasma GABA levels of 649 42 nM compared to 501 32 nM in controls (87)

There was no correlation between the GPx3 activity and CVD mortality in participants with higher HDLcs (P for interaction, 0.006)
