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NADPH, a metabolite of PPP, protects neurons from I/R-induced damage in rodent and primate stroke models (Li et al., 2016)

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Danshen-derived compound 1 (DHT) is a bioactive compound found in Danshen with cytotoxic effects against various malignant tumors

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Manipulating CSE and ETHE1 levels in both directions, we found a consistent pattern in that the two enzymes mirrored each other: silencing CSE yielded the same effect (slower radical removal) as overexpressing ETHE1, and overexpressing CSE yielded the same effect (faster radical removal) as silencing ETHE1 (Fig