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In addition, the vaccine improved the physical activity of middle-aged mice (50 weeks old) and extended the median lifespan of ZMPSTE24 KO mouse (model of progeria), an extreme model of accelerated aging 62

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Furthermore, some in vitro experiments have also found that AOD 9604 can affect the expression of related genes in adipocytes, such as promoting the expression of genes related to axunge breakdown and inhibiting the expression of genes related to axunge synthesis, thereby regulating axunge metabolism at the genetic level

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