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Heat shock proteins such as HSP70 which have stress-inducible expression and function as protective agents against cellular oxidative stress and inflammation, are found at elevated levels at sites with lipid accumulation (oxidized low-density lipoprotein) and activated macrophages, such as during the development of atherosclerotic plaques [68]

Certain histological characteristics of IC, such as the thinning of the bladder epithelium, erosion, and heightened mast cell infiltration, suggest that the condition may result from a deficiency in the regenerative capacity of bladder epithelial cells, along with immune system dysfunction (Slobodov et al., 2004)

[DOI] [PMC free article] [PubMed] [Google Scholar] 257.Cotton S.M., McCann T.V., Gleeson J.F., Crisp K., Murphy B.P., Lubman D.I

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