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These changes occurred before the increase in THDA levels, indicating that the loss of BDNF-TrkB signalling and upregulation of GSTO2 happens before the hyperdopaminergic state, as with the Trkb Penk -KO mice, supporting that GSTO2 increase is more likely a cause of neurodegeneration than a consequence of it

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In the context of wound healing, peptides are increasingly seen as promising agents for improving outcomes in both chronic and acute wounds due to their versatility, targeted mechanisms, and low immunogenicity

doi:10.1096/fj.09-142307 Malinda KM, Goldstein AL, Kleinman HK