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Major Criteria Skin hyperextensibility, with velvety skin texture and absence of atrophic scarring Generalized joint hypermobility, with or without recurrent dislocations (most commonly shoulder and ankle) Easily bruisable skin/spontaneous ecchymoses Minor Criteria Foot deformities (broad/plump forefoot

Taguchi T, Takao T, Iwasaki Y, Pooh K, Okazaki M, Hashimoto K, Terada Y

Bupropion tends to cause weight loss, whereas mirtazepine tends to cause weight gain

457 However, dual MEK/AKT inhibition with Trametinib and GSK2141795 did not yield clinical benefits in metastatic NRAS -mutant and wild-type melanoma, 458 indicating the limited spectrum of application of AKTi in melanoma with rather high heterogeneity