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Combinatory strategies of gene editing and marine bioactives could address CVD treatment and secondary prevention with a greater impact on human health

Mulberry fruit ameliorates Parkinsons-disease-related pathology by reducing alpha-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model

The titre of the vector stocks was estimated to be 5.4 10 8 transducing units per ml for the Gsto2 -shRNA and 5.1 10 8 transducing units per ml for the scrambled shRNA

Although many enzymes in one-carbon metabolism are affected by the sex hormones testosterone and estradiol, the main reasons for sexual dimorphism in glutathione metabolism are the effects of estradiol and the GSH regulatory motif, which includes the inhibition of GS and GCL by GSH itself [Figure 2B]

To assess if there was an effect of diet on the metabolome, the homogeneity of group variances (beta-dispersion) was tested, followed by permutational multivariate analysis of variance (PERMANOVA)