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10.1161/CIRCULATIONAHA.106.679597 Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ: Ceramide is a cardiotoxin in lipotoxic cardiomyopathy

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Additionally, a deficiency in reduced glutathione (GSH), which can be caused by antimalarial agents and sulfa antibiotics, has been found to positively correlate with PPP disorders ( In Bombyx mori , it has been observed that G6PDH activity remains consistently high during both diapause and embryonic development but experiences a rapid decline just before hatching (Suzuki and Miya, 1975)

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Approximately 2% of AD cases are caused by familial AD, whereas the remaining 98% are caused by sporadic AD