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while the first monoclonal antibody, muromonab-CD3, was FDA-approved in 1986, the first CAR-T approval, tisagenlecleucel, was as recent as 2017
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Rapid molecular platforms such as PCR sequencing GeneXpert and nanopore sequencing now detect clinically relevant mutations directly from specimens and thus expedite the management of MDR-TB and XDR-TB (Ren et al., 2024)
This pattern isn't new, either: SARMs (selective androgen receptor modulators) followed the exact same trajectory
