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Pyruvate Carboxylase Pyruvate carboxylase is the critical first enzyme in the conversion of pyruvate to glucose in the pathway of gluconeogenesis

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It would also reduce microclot formation due to endothelial damage caused by the positive regulation of NOX2 by EBNA-1 in EBV-transformed endothelial cells or by the activation of TLR3 by EBERs [256, 302, 316, 317]

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Several investigations focus on the application of GT for the treatment of PD, which focuses on gene delivery systems, CRISPR/Cas9 technology and NPs, and clinical applications and challenges (145, 146)