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Preclinical studies Age-related declining NAD + levels in aging have been observed in rodents and different human tissues, such as muscle, liver, and brain 58,240,241

We also see many individuals who follow strict vegetarian or vegan diets, which can increase the risk of B12 deficiency due to limited intake of animal-derived foods

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In the groups receiving the real Vitamin B12 injections they found a 32% decrease in perceived pain
