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Pharmacokinetic characterization in porcine models demonstrated an intravenous half-life of approximately 3 minutes, with rapid degradation via sequential amino-terminal amino acid removal and confirmed oral bioavailability

Patients in STEP 1 were desirous of weight loss as a reason for study participation and received structured lifestyle intervention (which included a 500 kcal per day diet with 150 min per week of physical activity)

The following standards were set