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Its also the antithesis of the body positivity movement

Human ACE2 expression is high in tubular epithelia (from kidney), and the viral hijack of this enzyme could alter sodium transport, affect blood volume/pressure and lead to AKI 308

Epidermal regeneration Source 19: Epidermal Differentiation in Barrier Maintenance and Wound Healing Source 20: The use of isotretinoin in acne Source 21: The effect of oral retinoid therapy on the normal human immune system Source 22: Cutibacterium acnes (formerly Proprionibacterium acnes) and Shoulder Surgery Source 23: Systemic isotretinoin therapy normalizes exaggerated TLR-2-mediated innate immune responses in acne patients Source 24: The immune system Source 25: iPLEDGE Risk Evaluation and Mitigation Strategy (REMS) Source 26: Pregnancy and isotretinoin therapy Source 27: Isotretinoin for Childhood Cancer Patients Source 28: Anencephaly: MedlinePlus Genetics Source 29: The etiopathogenic and morphological spectrum of anencephaly: a comprehensive review of literature Source 30: Isotretinoin Use and the Risk of Inflammatory Bowel Disease: A Case Control Study Source 31: StatPearls: Ulcerative Colitis Source 32: Despair Beneath His Wings Source 33: Does isotretinoin cause depression and suicide