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Although not FDA-approved for these indications, many patients and integrative or functional medicine practitioners report significant benefits

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Hepatic cytochrome P450 enzyme activity and renal clearance efficiency both decline with age, which could theoretically extend the dihexa half life in older subjects, but specific pharmacokinetic data stratified by age are not published for dihexa

Some useful therapies may be under-studied because they are difficult to commercialize, while others remain unapproved because early promise did not translate into meaningful human benefit or because safety questions remain