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These early NK-driven responses help limit HBV spread but can also cause liver injury by killing infected hepatocytes through Fas/FasL and TRAIL pathways (74)

Efferocytosis, a key anti-inflammatory mechanism is deficient in the lungs of patients with COPD

During the process of neurodegeneration, it is likely that excess cholesterol was converted into 24S-OHC in the neurons, leading to the up-regulation and increased expression of ApoE proportionally to the amount of neurodegeneration (Leoni and Caccia, 2011)

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These modifications can lead to mutations, genomic instability, and if not adequately repaired, contribute to carcinogenesis and other genetic disorders [39]