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of the study was IR B2022-DWFL-009

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In the last years, approaches to design future therapies consider novel aspects as, for example, heritability of GSH levels in different organs/tissues [190], regulation of epigenetic mechanisms as response to variations of glutathione level or GSH/GSSG ration [191]

Furthermore, the expression of endothelial transcription factors within human brain organoids promotes neuronal maturation and reduces cell death ( Other studies have been based on the co-culture of human umbilical vein endothelial cells (HUVECs) with pluripotent stem cells before neural induction, which generated a vascular system formed by the HUVECs in the brain organoids, called HUVEC-BOs (Shi et al., 2020)