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By blocking NNMT, 5-Amino-1MQ restores NAD+ availability, reactivates SIRT1-mediated mitochondrial biogenesis, and shifts substrate preference from glucose storage to lipid catabolism

They may differ from commercially available or FDA-approved drugs in efficacy, safety, risk, and side-effect profiles

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We assumed that a physician visit to explain to patients the benefits of oral therapy and instructions for use would take place on the day they came in to receive their intramuscular injection, and so this visit was not added to the conversion cost