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However, under certain pathological conditions, excessive changes in organ weight due to organ congestion and oedema, hyperplasia and hypertrophy, atrophy or degeneration will occur

This neurotrophic support is particularly crucial during the aging process, as reductions in BDNF have been related to cognitive deficits and an elevated risk of neurodegenerative disorders

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Together with other mediators, PDGF in turn promotes the metabolic effects of TGF up-regulation, activity of myofibroblasts, and recruitment of fibrotic cells, enhancing the ECM deposition and fibrotic plaque formation (Lucattelli et al., 2008)

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