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It has been well established that pro-inflammatory cytokines produced by the adipose tissue in obesity affect normal nutrition-related signalling, establishing the progression to MetS and ultimately to T2D [125]

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The same mice were recorded in two sessions with tesofensine (mouse name LH01 n = 15 and LH02 n = 16 neurons, total 31 neurons), whereas in two intercalated and contiguous sessions, the same mice received saline injections (mouse LH01 n = 16 and LH02 n = 20, in total 36 neurons)