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Infections: Certain parasites (like Giardia) or bacteria can inflame and damage the gut lining
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One of the advantages Holst's group had in working on the issue was that researchers in Copenhagen were skilled at keeping pancreases alive that had been removed from pigs by perfusion with artificial blood

[DOI] [PubMed] [Google Scholar] Schwiebert EM, Benos DJ, Egan ME, Stutts MJ, Guggino WB

doi:10.1001/jama.2021.4788
