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NHS Greater Glasgow and Clyde

Generalized congenital hypopigmentation, with the exception of Tietz syndrome, is usually associated with oculocutaneous albinism (OCA), either one of the classic subtypes of OCA (OA 14), or one of the forms of OCA with systemic manifestations such as HermanskyPudlak syndrome

It was previously discussed that under certain circumstances, such as in acidic pH in vitro, CRP adopts a different pentameric configuration that exposes a hidden ligand binding site for non-phosphocholine ligands, which also enables CRP to bind to immobilized, denatured, and aggregated proteins, regardless of the identity of the native biomolecule [42]

A deeper understanding of the molecular mechanisms underlying circadian regulation and effects of metabolic hormones may help developing new therapeutic strategies for treating metabolic disorders

doi: 10.1016/j.adengl.2019.09.003