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452.Clodi K, Asgary Z, Zhao S, Younes M, Wimmer D, Cabanillas F, Andreeff M, Younes A: B cells of Hodgkins disease (HD) may contribute to Reed-Sternberg (RS) cells survival by providing CD40 ligand (CD40L) survival signals in vivo

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The cell suspension was passed through a 70 m nylon mesh, centrifuged (300 g for 7 min at room temperature, 2021 C) and chondrocytes were seeded in DMEM (Gibco) containing 5.5 mM glucose (Sigma-Aldrich), 2 mM glutamine (Gibco), 1 mM sodium pyruvate (Gibco) and supplemented with 100 units per ml penicillin, 50 g ml 1 streptomycin and 10% FBS (hereafter referred to as growth medium) at a density of 18 10 4 cells per cm

702 These results emphasize the complex interplay between UPR branches and cellular degradative pathways, suggesting that the therapeutic manipulation of IRE1XBP1s signaling may need to be finely tuned