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Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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Day 3: Cruz del Condor Trip to Puno Natural spectacle of the flight of the condor and transfer to the shores of Lake Titicaca Very early after breakfast, we will head to the Cruz del Condor , the most famous viewpoint of the Colca Canyon, located 41 km from Chivay