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Description
This review highlights epidemiology, risk factors, genetics, pathogenesis, clinical manifestations, diagnostic methods, epigenetic mechanisms, and recent therapeutic advances

As TNF alpha is tumor-promoting [96, 97], the estrogen-mediated repression of TNF alpha may support a stronger anti-tumor immune microenvironment in bladder tumors of patients with female gonads

It becomes more sensitive to temperature and light

2019;26:62333.e9

This is why many patients report inconsistent or negligible outcomes
