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Collective findings from these studies underscore persistent translational challenges, including size heterogeneity, rapid renal clearance, and limited long-term toxicological data, highlighting the need for improved targeting, surface modification, and synthesis control to support clinical translation [91, 190]

The peptide improved healing in both ischemic and diabetic wound models (rats and pigs), producing organized collagen fiber alignment rather than random scarring (Pickart & Margolina, 2018)

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Research on neurotransmitter-system interactions has also been compiled in recent reviews, broadening the picture beyond the classical angiogenic and gastric framings (PMID 38675421)