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The diagnosis of nociplastic pain remains primarily clinical, relying on the recognition of a characteristic syndrome, widespread pain with associated somatic and cognitive symptoms, aided by questionnaires that capture central sensitization features and comorbid conditions (Figure 4)

Sub-cellular localization of IGF-1R (membranous, cytoplasmic, or nuclear) is an attractive candidate prognostic biomarker since it is readily assessable using biopsy tissue

Hence, ice nucleation was hindered by sealing this interface using mineral oil (see Fig

In functional practice, identifying and addressing mast cell involvement is essential

As in other amino acids with an asymmetric carbon atom, the L-isomers of Met, Hcy, and Cys are the biologically active forms