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doi: 10.3389/fphar.2022.881835
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During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)
Thus, while transcriptional changes mediated by NHR-49 correspond with the maintenance of energy homeostasis during fasting, animals possessed the capacity to restore their ATP levels upon nutrient replenishment
