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Besides, it stimulated expression of early growth response 1 (egr-1) gene responsible for cytokine and growth factor generation and early extracellular matrix (collagen) formation (but also its repressor nerve growth factor 1-A binding protein-2 (nab2)) (44)

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345 (4) Complement system COVID-19 is characterized by severe pulmonary inflammation and activation of coagulation, leading to adverse disease outcomes associated with the activation of the complement system, particularly the C5A-C5AR axis

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