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Human nasal epithelial cells (HNEpCs) and primary macrophages were cultured to track the cellular origin of oxidative stress in nasal polyps(NPs) and to determine whether crocin can reduce cellular inflammation by increasing the cellular antioxidant capacity

The detailed description of the protocol used as well as demographic and clinical characteristics of participants have been described in a separate study previously published ( To further assess the effect of NAC treatment in modulating host immune response, we measured the concentration of several cytokines, chemokines, growth factors and lipid mediators in plasma isolated from patients receiving or not NAC at the study baseline and day 60 of treatment (see Methods for details in the choice of the parameters)

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Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone