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Tumor cell fragments killed by PDT are phagocytosed by macrophages, leading to acute inflammation, leukocyte infiltration, and dendritic cell activation [18]
Viral infections activate endosomal NOX2 oxidase and restrict TLR7 signaling, and inhibition of endosomal NOX2 decreases viral pathogenicity 42

Representative natural products coordinated with Fe 3+/2+ were summarized in Table 2

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Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone