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Even Avecho Biotechnology (formerly Phosphagenics), a company who wanted to repurposed AOD-9604 as a transdermal formulation, knew why the clinical trials failed: AOD9604s delivery could have been the key issue

Obesity Pissios (2017) "NNMT: more than a vitamin B3 clearance enzyme." Published in Trends in Endocrinology & Metabolism

PMID: 31527485

According to a study published in PubMed Central (NIH), IV administration of vitamin B12 provides a faster increase in B12 levels compared to oral supplementation, making it a potentially better option for patients with severe deficiency