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IL-6 -/- mutant mice exposed to the same cytokine storm-inducing stimuli exhibited improved lung function, decreased edema, decreased lung pathology on hematoxylin/eosin stain as compared to wild-type specimens

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Yet, promoting tissue repair with local delivery of recombinant cytokines or growth factors usually requires the use of a delivery system that ideally allows retention of low doses of the therapeutic at the delivery site and limits its diffusion to prevent side effects