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In the world of biochemistry, this initial conversion is known as the "rate-limiting step." This means that the TPH enzyme acts as a strict biological bottleneck, tightly controlling and limiting exactly how much serotonin the body is allowed to produce at any given time, regardless of how much L-tryptophan you consume in your diet

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Therapy and Prognosis Revised treatment standards over the last years have significantly improved outcome and prognosis (21)

doi: 10.1097/HEP.0000000000000369

ABCG2 ), multidrug resistance protein 2 (MRP2