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Upregulation of NCOA4 promotes lysosomal degradation of ferritin, leading to a sharp expansion of the intracellular labile iron pool, which provides the essential iron substrate for ferroptosis and directly lowers the threshold for ferroptosis initiation (83)
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The Liver and Oxidative Stress The liver is a metabolic powerhouse that performs over 500 vital functions
doi: 10.1093/oxfordjournals.aje.a117403
Phase 2 interim data showed reduced bleeding episodes by over 50% across all dose cohorts
