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Main-chain water-soluble polyphosphoesters: Multi-functional polymers as degradable PEG-alternatives for biomedical applications

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Ultimately, elucidating the mechanisms that govern transitions between protective and pathological states will be critical to refine classification systems and to guide therapeutic strategies targeting astrocyte reactivity

These drugs can induce apoptosis and disrupt cellular homeostasis, leading to irreversible SHL

In all isoforms enzymatic function depends on the conserved peroxidatic cysteine residue contained within an active-site conserved across all isoforms as well as cysteine in the carboxy-terminal region functional in some of the PRDX isoforms