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Once inside the cell, it is used to make adenosylcobalamin, needed for energy production in mitochondria, or interacts with 5-MTHF to become methylcobalamin during homocysteine metabolism

Finally, we review the therapeutic implications of these discoveries with the use of both epigenetic clocks as predictors and the development of epidrugs that target the DNA methylation/demethylation machinery

Ma et al., 2021)

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Arch Gen Psychiatry 2000
