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Ann N Y Acad Sci 1031:249262

i.p, Intraperitoneal perfusion

For those with risk factors like kidney disease, liver failure, or high blood pressure, long-term medication use can also present specific dangers

doi: 10.1152/jn.1999.81.5.2131

The hypothesis that these reactive intermediates are responsible for cell death is supported by the observation that a cell line selected for erastin resistance showed several-hundred-fold upregulation of AKR1C family genes (Dixon et al., 2014), which encode aldoketoreductases that, among other functions, reduce reactive end-products of lipid peroxidation to unreactive compounds (MacLeod et al., 2009)