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Combined with the possibility that high concentrations of ROS activate the ER stress-mediated cell death pathway, Wei et al (69) further assessed the transcription factors associated with ER stress pathways and reported that B2 increased the mRNA expression of binding immunoglobulin protein in H460 cells and thus the mRNA expression of ATF-4 and X-box binding protein (XBP-1)

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The classic Russell mechanism involves the combination of two peroxyl radicals followed by the elimination of singlet oxygen and formation of one alcohol and one ketone