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The role of cellular protection in response to ROS accumulation has been reported, and the signal of preconditioning that leads to this protection was related to Hormesis, which means a dose-response relationship of ROS, at low levels, generates a stimulus of neurodegenerative diseases, while its accumulation (high concentration) generates an inhibition of the effect through preconditioning [21-23]

10.1111/j.1365-2125.2012.04425.x Br J Clin Pharmacol

[PubMed: 12959451] 267

Its clinical manifestations include motor symptoms, such as bradykinesia, resting tremor, myotonia, and postural balance disorders, and non-motor symptoms, such as hyposmia, sleep disturbance, constipation, and mental and cognitive impairment (1)

However, the efficiency of MG detoxification by the glyoxalase I-II system strongly relies on the GSH level in plants [50, 51], evidenced as the significant contribution of non-enzymatic antioxidants to the glyoxalase system (Fig