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Description
Aberrant activation of Drp1 disrupts mitochondrial homeostasis, thereby triggering NLRP3 inflammasome activation and caspase-3 cleavage, which in turn amplify neuroinflammatory cascades (Sbai et al., 2023)
IN-NAP Therapies for Neurodegenerative Disorders 7.2.1
10.1038/s41467-018-08093-x
Sublingual and nasal formulations are alternative options, though evidence supporting superior efficacy over oral tablets is limited
doi: 10.1080/21641846.2019.1653471 33 GandaseguiIMLakaLAGargiuloPAGomez-EstebanJCSanchezJVL
