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In response, macrophages and other immune cells attempt to engulf and neutralize the particles, often resulting in the formation of granulomasorganized collections of immune cells and epithelial cells that encapsulate foreign materials to isolate them from the surrounding tissue, often associated with chronic inflammation [117,118,119,120]

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First, contrary to the previous results, the 2 -AR, was shown to activate ERK1/2 in cells lacking both -Arrs (OHayre et al., 2017

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Based on current research, Activating Transcription Factor 2 (ATF2) was widely recognized as an important transcription factor involved in regulating various biological processes, including cell proliferation, apoptosis, and stress responses[37, 38]

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